Senior AI Applications Engineer

Twin Health 

At Twin Health, we empower people to improve and prevent chronic metabolic diseases, like type 2 diabetes and obesity, with a new standard of care. Twin Health is the only company applying AI Digital Twin technology exclusively toward metabolic health. 

We start by building a dynamic model of each person’s metabolism — drawing on thousands of data points from CGMs, smartwatches, and meal logs — that maps their personal path to better health. Guided by a dedicated clinical care team, our members have lowered their A1C below the diabetes range, achieved lasting weight loss, and reduced or even eliminated medications, all while living healthier, happier lives.

Working here 

Our team at Twin Health is passionate, talented, and united by a shared purpose: to improve the metabolic health and happiness of our members. We believe in empowering every Twin to make a meaningful impact for our members, our clients, and each other, while enjoying a supportive, collaborative work environment.

Twin has been recognized not only for our innovation but also for our culture, including: Innovator of the Year by the Employer Health Innovation Roundtable (EHIR), selected to CB Insights’ Digital Health 150, and named one of Newsweek’s Top Most Loved Workplace® .

With more than $100 million raised in recent funding, including a $53 million Series E round in 2025 led by Maj Invest, and a $50 million investment in 2023 led by Temasek, Twin is scaling rapidly across the U.S. and globally. Backed by leading venture firms like ICONIQ Growth, Sequoia, Sofina, Temasek, and Peak XV, we are building the most impactful digital health company in the world.

Join us as we reinvent the standard of care in metabolic health.

Opportunity

We are looking for a Senior AI Applications Engineer to join our team and play a key role in shaping the next generation of deeper activity experiences. This is an exciting opportunity to work at the intersection of backend engineering and device integrations, collaborating closely with backend, mobile, and AI engineers, as well as clinical teams, to build innovative solutions. Your work will empower members with personalized experiences that enhance engagement and support overall metabolic well-being.

Responsibilities 

• Lead the design, development, and deployment of sophisticated AI agents and tools that streamline clinical decision-making, automate complex administrative tasks, and enhance clinical workflows.
• Explore and implement the full-stack architecture required for AI-agentic systems, from context engineering, MCP servers, to API design and deployment.
• Architect and build robust, scalable backend services and integrations (using Python, Java Spring Boot, SQL) that serve as the foundation for our AI applications.
• Collaborate with cross-functional teams to shape the user experience of AI systems, translating clinical and operational needs into concrete technical specifications and prototypes.
• Champion best practices for developing reliable, secure, and scalable AI applications, ensuring all solutions meet compliance standards such as HIPAA.
• Mentor and coach other engineers, modeling cross-functional thinking and helping to elevate the team’s capabilities in building AI-driven products.
• Monitor and optimize the performance of AI systems in production to handle rapid growth and ensure a seamless user experience.
• Take on additional responsibilities as needed, including on-call rotations.
• Regular travel to our Menlo Park headquarters for planning workshops and team collaboration sessions.
• Other duties as assigned.

Qualifications 

• Bachelor’s degree in Computer Science or a STEM-related field (Master’s preferred).
• 5+ years of software engineering experience, with a strong foundation in building backend services.
• Demonstrated experience in developing and deploying AI-powered applications using Large Language Models (LLMs) like GPT, Claude, or Gemini.
• Strong practical knowledge of prompt engineering, vector databases, Retrieval-Augmented Generation (RAG), and other techniques for building reliable LLM-based systems.
• Proficiency in Java and/or Python and experience developing microservices.
• Hands-on experience with SQL databases (PostgreSQL, MySQL) and query optimization.
• Proven ability to work across disciplines, collaborating effectively with product, design, and non-technical stakeholders to build user-centric solutions.
• Excellent communication skills and a demonstrated ability to navigate ambiguity and drive projects from concept to completion.
• Experience in healthcare, biosensors, or related fields is a plus but not required.
• This remote opportunity based out of the U.S. Applicants must be authorized to work for any employer in the U.S.

Compensation and Benefits  

The compensation range for this position is $195,000-$210,000 annually. 

Twin has an ambitious vision to empower people to live healthier and happier lives, and to achieve this purpose, we need the very best people to enhance our cutting-edge technology and medical science, deliver the best possible care, and turn our passion into value for our members, partners and investors. We are committed to delivering an outstanding culture and experience for every Twin employee through a company based on the values of passion, talent, and trust. We offer comprehensive benefits and perks in line with these principles, as well as a high level of flexibility for every Twin

• A competitive compensation package in line with leading technology companies
• A remote and accomplished global team
• Opportunity for equity participation 
• Unlimited vacation with manager approval
• 16 weeks of 100% paid parental leave for delivering parents; 8 weeks of 100% paid parental leave for non-delivering parents
• 100% Employer sponsored healthcare, dental, and vision for you, and 80% coverage for your family; Health Savings Account and Flexible Spending Account options
• 401k retirement savings plan

Salary range for US jobsUS Salary Range$195,000—$210,000 USD

We have been made aware of fraudulent interview requests being sent using the Twin Health's name. All communications will come from official Twin Health channels and a twinhealth.com email address. We will never ask you to complete a text interview or request financial details during the interview process.